The Complete Guide to Resveratrol: Benefits, Dosage, and Safety

What Is Resveratrol?

Healthylife describes resveratrol as an antioxidant and more specifically a phenolic bioflavonoid (a type of polyphenol). Healthylife lists food sources that are naturally high in resveratrol, including the skin of grapes, blueberries, raspberries and mulberries, and also mentions peanuts, red wine and dark chocolate as foods where it can be found.

Myprotein AU notes that “trans-resveratrol” is an isomer (molecular form) of resveratrol, and states trans-resveratrol is considered to have greater biological activity than cis-resveratrol (as described on their page).

Sources: Healthylife, Myprotein AU

How Resveratrol Works in the Body

Healthylife states resveratrol exerts anti-inflammatory and antioxidant actions in the body. Myprotein AU similarly describes resveratrol as having antioxidant and anti-inflammatory effects, and explains some proposed mechanisms (for example, mentioning induction of a protein called PGC-1 and discussion of “sirtuins” in relation to ageing mechanisms on that page).

Exactly how resveratrol changes specific clinical biomarkers in humans (including dose-response relationships and time-to-effect): Not specified on the source page.

Sources: Healthylife, Myprotein AU

Key Benefits: What the Evidence Says

Important: Some statements below are presented as general education content (Healthylife, Myprotein AU) and some are product-positioned claims (Naturecan AU, Myprotein product page). Where the source page does not provide human evidence quality, effect sizes, or clear outcomes, it is marked “Not specified on the source page.”

Antioxidant and anti-inflammatory effects

Healthylife describes resveratrol as a polyphenol with anti-inflammatory and antioxidant actions. Healthylife’s longevity article also notes resveratrol is known for antioxidant and anti-inflammatory effects, while stating evidence for “anti-aging” in humans is limited (as discussed on that page). Myprotein AU similarly discusses antioxidant and anti-inflammatory effects.

Which specific inflammation markers change, and what magnitude of benefit is seen in humans: Not specified on the source page.

Sources: Healthylife, Healthylife (Longevity), Myprotein AU

“Anti-ageing” and longevity (how strong is the evidence?)

Healthylife reports that resveratrol has been studied in microbes, insects, fish, worms and animals, and states increased lifespan has been observed in those models. However, Healthylife also states these results have not been confirmed in humans, and their longevity supplements article notes there is limited evidence from animal studies behind “anti-aging” claims.

Reliable, consistent evidence of lifespan extension in humans: Not specified on the source page (and Healthylife explicitly notes animal evidence and lack of confirmation in humans).

Sources: Healthylife, Healthylife (Longevity)

Heart and cardiovascular positioning

Healthylife discusses resveratrol in the context of heart health and mentions it has been proposed as one explanation for the “French paradox” observation related to red wine consumption (as described on that page). Naturecan AU positions their resveratrol capsules as designed to support cardiovascular health and overall well-being, and includes “may improve cardiovascular health” as a listed benefit on the product page.

Human clinical outcomes (blood pressure, LDL/HDL changes, events reduction) tied to specific doses: Not specified on the source page.

Sources: Healthylife, Naturecan AU

Brain health and neuroprotection (claim-level summary only here)

Myprotein AU states resveratrol has been seen to have protective effects on the nervous system and discusses “neuroprotection” in the context of degenerative neurological conditions (as presented on that page). Healthylife’s resveratrol article also lists “brain” and “overall health” among areas it discusses resveratrol in relation to dietary intake.

Which conditions, what outcomes, and how meaningful the effects are in humans: Not specified on the source page.

Sources: Myprotein AU, Healthylife

Who Might Benefit Most

• People who want a polyphenol-focused antioxidant supplement: Healthylife and Myprotein AU describe resveratrol’s antioxidant and anti-inflammatory actions.
• People comparing “trans-resveratrol” products: Myprotein AU explains trans-resveratrol as one form (isomer) of resveratrol and positions it as having greater biological activity than cis-resveratrol (as stated on that page).
• People who prefer dietary sources first: Healthylife lists foods naturally high in resveratrol (e.g., grape skin and dark-coloured berries).

Specific populations who should take resveratrol for named medical conditions: Not specified on the source page.

Sources: Healthylife, Myprotein AU

Recommended Dosage and How to Take It

A single universal “best” dose for resveratrol across all products: Not specified on the source page. Doses vary widely, so the safest, most accurate approach is to follow the label of the specific product you choose.

Label examples from allowed sources:

• Naturecan AU Resveratrol Capsules: 500 mg of resveratrol per capsule; “Simply take one 500 mg capsule per day at the time that best suits your needs.” Source
• iHerb AU (Solgar Resveratrol 500 mg): “As a dietary supplement for adults, take one (1) capsule daily, preferably with a meal…” Source
• iHerb AU (Source Naturals Resveratrol 500 mg): Suggested use: “1 tablet daily.” Source
• Myprotein AU Trans-Resveratrol Tablets: listed as 125 mg per serving and 98% extract (as shown on the product page). Source

High-dose protocols, cycling, or condition-specific dosing plans: Not specified on the source page.

Best Time to Take Resveratrol (Timing and With/Without Food)

Naturecan AU states to take one capsule per day at the time that best suits your needs (meal timing not stated in that dosing sentence). Solgar’s iHerb AU listing suggests taking one capsule daily preferably with a meal.

Morning vs evening performance differences (energy, sleep, workouts): Not specified on the source page.

Sources: Naturecan AU, iHerb AU (Solgar)

Forms and Quality: What to Look For on the Label

• Resveratrol vs trans-resveratrol: Myprotein AU discusses trans-resveratrol as one isomer of resveratrol and describes it as having greater biological activity than cis-resveratrol (as presented on that page).
• Dosage per serve: Products range from 125 mg per serving (Myprotein product page) to 500 mg per capsule/tablet (Naturecan AU; iHerb AU examples).
• Vegetarian/vegan suitability: Naturecan AU states their capsules are suitable for vegans; Solgar’s iHerb listing is in vegetable capsules.
• Testing/transparency: Naturecan AU states the product is third-party tested and links to a certificate of analysis on their page (certificate link is hosted on a different domain, so it is not linked here).

Independent brand-to-brand purity comparisons or lab-based rankings: Not specified on the source page.

Sources: Naturecan AU, Myprotein AU, Myprotein AU product, iHerb AU (Solgar)

Side Effects and Who Should Avoid It

Side effects for resveratrol supplements (common, uncommon, and dose-related): Not specified on the source page in the sources used here.

However, an iHerb AU product page (Source Naturals Resveratrol 500) includes warnings stating it is not for use by pregnant or breastfeeding women (or if you may become pregnant) and advises consulting a physician if you are taking anticoagulant medications or any prescription drugs. It also advises discontinuation if abdominal pain, watery/increased stools, or diarrhoea develop (as stated on that page).

Source: iHerb AU (Source Naturals)

Drug and Supplement Interactions

An iHerb AU product warning (Source Naturals Resveratrol 500) advises that if you are taking anti-coagulant (blood-thinning) medications or any prescription drugs, you should consult your physician before use.

Specific interaction details (which medicines, clinical magnitude, and monitoring): Not specified on the source page.

Source: iHerb AU (Source Naturals)

FAQs

1) What foods contain resveratrol?

Healthylife lists sources including the skin of grapes, blueberries, raspberries and mulberries, and also mentions peanuts, red wine and dark chocolate.

Source: Healthylife

2) What’s the difference between resveratrol and trans-resveratrol?

Myprotein AU explains trans-resveratrol is one isomer (molecular form) of resveratrol (with cis-resveratrol being the other) and states trans-resveratrol is considered to have greater biological activity than cis-resveratrol (as described on that page).

Source: Myprotein AU

3) Is resveratrol proven to increase human lifespan?

Healthylife states lifespan increases were observed in animal and other non-human models, but those results have not been confirmed in humans. Healthylife’s longevity article also notes limited evidence from animal studies behind “anti-aging” claims.

Sources: Healthylife, Healthylife (Longevity)

4) What dose should I take?

There is no single universal best dose listed across the sources. Examples include Naturecan AU’s label direction of one 500 mg capsule per day, Solgar’s iHerb AU direction of one capsule daily (preferably with a meal), and Source Naturals’ iHerb AU direction of 1 tablet daily. Always follow your specific product label and seek medical advice if you take medication.

Sources: Naturecan AU, iHerb AU (Solgar), iHerb AU (Source Naturals)

5) Who should be cautious with resveratrol supplements?

An iHerb AU product warning (Source Naturals) advises against use if pregnant or breastfeeding (or if you may become pregnant) and recommends consulting a physician if you use anticoagulant medications or prescription drugs.

Source: iHerb AU (Source Naturals)

Optional: Shop Resveratrol

[Shop Naturecan AU Resveratrol Capsules: https://www.naturecan.com.au/products/resveratrol-supplements]

[Browse Resveratrol products on iHerb AU: https://au.iherb.com/search?kw=resveratrol]

Disclaimer: This article is general information only and is not medical advice. If you are pregnant or breastfeeding, under 18, have a medical condition, or take prescription medication, speak with your GP or pharmacist before starting supplements.

Sources (allowed domains only): Healthylife (Resveratrol—health benefits of berries, red wine and chocolate), Healthylife (Longevity supplements), Naturecan AU (Resveratrol Capsules), Myprotein AU (What is trans-resveratrol?), Myprotein AU (Trans-Resveratrol Tablets), iHerb AU (Source Naturals Resveratrol 500), iHerb AU (Solgar Resveratrol 500mg)