- Core Mitochondrial Support Nutrients
These directly aid the mitochondria in producing ATP (energy) and improving efficiency.
Coenzyme Q10 (Ubiquinol form preferred) – Essential for the electron transport chain; ubiquinol is more bioavailable, especially for people over 40.
Acetyl-L-Carnitine (ALCAR) – Transports fatty acids into mitochondria for energy and may improve mental clarity.
Alpha-Lipoic Acid (ALA) – A potent antioxidant that also regenerates other antioxidants like vitamin C and E.
Magnesium (Magnesium malate or glycinate) – Supports ATP production and muscle function.
- Mitochondrial Biogenesis Activators
These help create new mitochondria and repair existing ones.
PQQ (Pyrroloquinoline Quinone) – Stimulates mitochondrial growth and improves energy metabolism.
Resveratrol or Pterostilbene – Activates sirtuins (SIRT1), linked to mitochondrial biogenesis.
Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) – Boost NAD+ levels, essential for mitochondrial function and repair.
- Antioxidants & Protective Compounds
These protect mitochondria from free radical damage.
Vitamin C & Vitamin E (mixed tocopherols) – Neutralize oxidative stress in and around mitochondria.
Glutathione (liposomal or NAC precursor) – Master antioxidant protecting mitochondrial membranes.
Astaxanthin – Potent antioxidant that protects mitochondrial membranes from oxidative stress.
- Mitochondrial Membrane & Cell Structure Support
Omega-3 Fatty Acids (DHA & EPA) – Maintain mitochondrial membrane fluidity.
Phosphatidylcholine – Supports mitochondrial and cell membrane repair.
- Lifestyle & Co-factors for Regeneration
Supplements work best alongside habits that stimulate mitochondrial renewal:
Intermittent fasting or time-restricted eating – Triggers mitophagy (removal of damaged mitochondria).
High-intensity interval training (HIIT) – Strong stimulus for mitochondrial biogenesis.
Cold exposure – Activates mitochondrial density in brown fat.
✅ Safety Note:
If you have rheumatoid arthritis or are on methotrexate/Olumiant (as you mentioned before), certain supplements like high-dose antioxidants, resveratrol, or immune-modulating compounds might interact with your treatment. It’s best to get your rheumatologist’s approval before starting a full mitochondrial stack.


